Summary

ELECTROPHYSIOLOGIE ex vivo

Experimental models

  Rodent brain slices           Zebrafish Larva

Readouts

• Intrinsic membrane properties
• Action potential firing and excitability
• Microcircuit synaptic connectivity
• Synaptic plasticity
• Ion channel biophysical properties
• Morphological neuron reconstruction

Applications

• Mechanisms of basic neuronal processes
• Functional mechanisms underlying/related pathological disorders
• Therapeutic perspective for human cognitive or neurological impairments
• Developmental profile of neuronal properties and activity
• Pharmacology

Highlights

Characterization of preclinical models recapitulating human disease
Functional and morphological alterations in a mouse model of epilepsy Publication  
Optogenetics
Activation of light-sensitive ion channels (opsins) to control neuron activity  Publication

Other Ephys services

In vitro patch clamp Multielectrode array